From higher education to high rises, hospitals, and hotels, Route 49 connects University City to the Philadelphia neighborhoods of Strawberry Mansion, Brewerytown, Fairmount, Spring Garden, Logan Square, and Grays Ferry. It also serves Amtrak 30th Street Station and the Ben Franklin Parkway.
It is part of SEPTA's continuing efforts to improve transit access to employment destinations.
Beginning Sunday, February 24, 2019, Route 49 will operate seven days a week and will offer frequent service. Peak weekday trips will run every 15 minutes, with midday service every 20 minutes, and evening trips every half-hour. Weekend service will run every 20 minutes midday, and 30 minutes in the morning and evening. For a schedule and map, click here.